To observe the effect of salvianolic acids on patients of coal worker’s pneumoconiosis complicated with chronic pulmonary disease in acute period. Methods： Seventy-eight patients with coal worker’s pneumoconiosis complicated with chronic pulmonary were randomly assigned into treatment group (n=39) and control group (n=39). Salvianolic acids were taken orally by patients in treatment group, and the control group gave patients conventional treatment of western medicine. The treatment course was 14 days. Results： Compared with control group, the clinical manifestation,blood hemorrheology, arteria blood gases and cardiac enzymes were improved evidently in treatment group,the difference was statistically significant(P<0.05). Conclusion： Salvianolic acids is effective in treating coal worker’s pneumoconiosis complicated with chronic pulmonary disease in acute period.