To study anti-inflammatory and analgesic effects of Hongyuan granule. Methods： The inhibitory effects were studied by observing xylene-induced swelling ear in mice, acetic acid-induced increase of abdominal capillary permeability in mice, carrageenin- induced paw edema and cotton ball-induced proliferation of granuloma in rats, hot-induced pain and acetic acid-induced writhing in mice. Results： Hongyuan granule significantly reduced swelling ear in mice (P<0.05), decreased abdominal capillary permeability in mice (P<0.05), evidently relieved paw edema in rats (P<0.05), and remarkably inhibited proliferation of granuloma in rats (P<0.01 or P<0.05), notably alleviated pain induced by hot plate (P<0.05), as well as obviously reduced the writhing times in mice (P<0.05). Conclusion： Hongyuan granule has obvious anti-inflammatory and analgesic effects.