| 引用本文:段娟娟 孙建宁 方 芳 何爱先 裴文慧.红元颗粒抗炎镇痛作用的研究[J].世界中医药,2014,9(04):. |
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| 红元颗粒抗炎镇痛作用的研究 |
| Study on Anti-inflammatory and Analgesic Effects of Hongyuan Granule |
| 投稿时间：2014-09-22 |
| DOI：10.3969/j.issn.1673-7202.2014.04.024 |
| 中文关键词: 红元颗粒 抗炎 镇痛 |
| English Keywords:Hongyuan granule Anti-inflammatory Analgesic |
| 基金项目:北京中医药大学科研创新团队资助项目（编号：2011-CXTD-12） |
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| 中文摘要: |
| 目的：研究红元颗粒的抗炎镇痛作用。方法：观察其对二甲苯致小鼠耳廓肿胀、冰醋酸致小鼠腹腔毛细血管通透性增高、角叉菜胶致大鼠足跖肿胀、棉球诱导大鼠肉芽肿、冰醋酸致小鼠扭体反应及小鼠热板实验的抑制作用。结果：红元颗粒可以明显抑制二甲苯致小鼠耳廓肿胀（P<0.05），降低冰醋酸致小鼠腹腔毛细血管通透性增加（P<0.05），减轻角叉菜胶致大鼠足跖肿胀（P<0.05），抑制棉球肉芽肿增生（P<0.01或P<0.05），显著减轻热刺激引起的小鼠疼痛（P<0.05）；减少小鼠扭体次数（P<0.01）。结论：红元颗粒具有显著的抗炎镇痛作用。 |
| English Summary: |
| To study anti-inflammatory and analgesic effects of Hongyuan granule. Methods： The inhibitory effects were studied by observing xylene-induced swelling ear in mice, acetic acid-induced increase of abdominal capillary permeability in mice, carrageenin- induced paw edema and cotton ball-induced proliferation of granuloma in rats, hot-induced pain and acetic acid-induced writhing in mice. Results： Hongyuan granule significantly reduced swelling ear in mice (P<0.05), decreased abdominal capillary permeability in mice (P<0.05), evidently relieved paw edema in rats (P<0.05), and remarkably inhibited proliferation of granuloma in rats (P<0.01 or P<0.05), notably alleviated pain induced by hot plate (P<0.05), as well as obviously reduced the writhing times in mice (P<0.05). Conclusion： Hongyuan granule has obvious anti-inflammatory and analgesic effects. |
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