To analyze the preponderant efficacy of traditional Chinese medicine in treating minimal hepatic encephalopathy (MHE). Methods： The basic and clinical researches on Chinese medicine in treating MHE were reviewed, experience of TCM differentiation was summarized and the preponderant efficacy was analyzed. Results： The preponderant efficacy of TCM to treat MHE was relevant to enhancing intelligence level, improving liver function, reducing blood ammonia level and decreasing the side-effect of western medicine. Conclusion： TCM to treat MHE emphasizes on both physical and mental therapy, and it can exert multiple advantages, its effect on MHE was generally accepted. While the study on MHE is just at primary level, further researches on TCM treating MHE are needed.