To investigate the dynamic changes of TCM syndromes in patients with liver cirrhosis.Methods： One to three years of follow-ups were conducted to 86 patients with liver cirrhosis to collect TCM information of the four diagnostic methods at different time. Cluster analysis was used to compare and analyze the two main symptoms， signs and TCM syndrome factor scores. Results： The symptoms of patients with liver cirrhosis showed clinical signs for yin deficiency of liver and kidney. As for TCM syndrome integral， yin deficiency of liver and kidney syndrome factor score was significantly higher than other syndrome group. The scores of yin deficiency and blood heat， stagnation of liver qi， deficiency of spleen and kidney yang were obviously increased compared with the outcomes of the first follow-up visit (P<0.05). The scores of liver and kidney deficiency， spleen deficiency and exuberant dampness did not change significantly during the two follow-ups(P>0.05). Conclusion： The characteristics of TCM syndromes in patients with liver cirrhosis manifests deficiency-excess complication， and the deficiency is mainly of liver and kidney yin deficiency， which aggravates with the development of the disease.