| 引用本文:赵长青 徐列明.扶正化瘀胶囊/片治疗肝纤维化和肝硬化的临床研究进展[J].世界中医药,2014,9(05):. |
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| 扶正化瘀胶囊/片治疗肝纤维化和肝硬化的临床研究进展 |
| Progress of Clinical Studies on Fuzheng Huyu Capsule/Tablet in Treating Liver Fibrosis and Liver Cirrhosis |
| 投稿时间：2014-03-17 |
| DOI：10.3969/j.issn.1673-7202.2014.05.006 |
| 中文关键词: 扶正化瘀胶囊/片 肝纤维化 肝硬化 |
| English Keywords:Fuzhen Huayu capsule/tablet Liver fibrosis Liver cirrhosis |
| 基金项目:上海市教育委员会重点学科（第五期）建设项目（编号：J50307）；上海市高校创新团队建设项目（第一期）；国家中医药管理局中医肝胆病重点学科(编号：2010sh) |
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| 中文摘要: |
| 本文综述2010—2013年发表的扶正化瘀胶囊/片临床研究论文。扶正化瘀胶囊/片临床治疗肝纤维化和肝硬化疗效明确，用以治疗肝硬化并发症，也取得较好疗效。数十项临床研究证实，扶正化瘀胶囊/方与抗乙肝病毒的核苷类（核苷类似物）药物、普通干扰素或聚乙二醇干扰素、熊去氧胆酸以及其他药物联用，治疗慢性乙型肝炎和其他慢性肝病所致肝纤维化和肝硬化，提高了疗效。此外，也开展了利用人体样本揭示扶正化瘀胶囊的临床作用机制的研究。扶正化瘀胶囊/片的未来研究，可能会有如下趋势：1）扩大适应证；2）进一步联合应用其他药物以提高临床疗效；3）优化组方；4）开展新剂型的研究；5）进一步揭示扶正化瘀复方的作用机制。 |
| English Summary: |
| This article summarizes the clinical studies published during 2010 to 2013 on Fuzheng Huayu capsule/tablet. Fuzheng Huayu capsule/tablet shows definite curative effects in treating liver fibrosis， liver cirrhosis and its complications. Several clinical studies have confirmed that Fuzheng Huayu capsule/tablet can treat liver fibrosis and cirrhosis caused by hepatitis B virus and other chronic liver diseases， can improve the curative effects by combining with nucleoside/nucleotide analogues， interferon/pegylated interferon， ursodesoxycholic acid or other drugs. In addition， studies of using human samples to reveal the mechanisms of Fuzheng Huayu capsule/tablet were carried out too. The future studies of Fuzheng Huayu capsule/tablet may have the following trends： 1) to expand indication; 2)to improve the curative effects by combining with more other drugs; 3) to optimize the formula; 4) to develop new dosage forms; 5) to further reveal the mechanisms of Fuzheng Huayu capsule/tablet. |
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