世界中医药

目的：探讨复方甘草酸苷联合丹皮酚软膏治疗变应性接触性皮炎(ACD)的临床。方法：96例ACD患者被随机分为对照组和治疗组，每组各为48例。对照组口服复方甘草酸苷片3次/d，2片/次。治疗组在对照组基础上外用丹皮酚软膏，2次/d。治疗后观察和比较两组临床疗效、症状积分和免疫因子水平变化及不良反应情况。结果：治疗组治疗后痊愈率和总有效率分别达到66.67%和85.42%，显著高于对照组痊愈率和总有效率(P<0.05)；治疗组治疗1、2和3周后症状积分分别为（5.23±1.1）分、（3.07±1.08）分和（1.32±0.82）分，均显著低于治疗前和对照组治疗后水平(P<0.05)；治疗后sIL-2R为(2.11±0.76)ng/mL，显著低于对照组(P<0.05)，而IL-2和IFN-γ水平为(28.14±2.37)pg/mL和(28.04±11.06)pg/mL，显著高于对照组(P<0.05)；两组不良反应率无统计学意义(P<0.05)。结论：口服复方甘草酸苷联合外用丹皮酚软膏，能显著改善ACD患者症状评分，降低炎性因子水平，不良反应少，疗效显著优于单用复方甘草酸苷。

English Summary:

To investigate the clinical observation of glycyrrhizic acid compound combined with Paeonol on allergic contact dermatitis (ACD).Methods： Ninety six patients with ACD were randomly divided into the control group (n=48) and the observation group (n=48). The control group applied oral compound glycyrrhizin glucoside tablets three times a day， two tablets each time. The observation group applied Paeonol ointment topically two times a day except form the treatment of the control group. The clinical curative effect， symptom integral and immune factor level change as well as the adverse reactions between two groups after treatment were observed and compared. Results： The curative rate and total effective rate after treatment in the observation groups were 66.67% and 85.42% respectively， which were both significantly higher than those of the control groups (P<0.05). The symptoms integral scores after 1， 2， and 3 weeks of treatment in the observation group were (5.23±1.1) points， (3.07±1.08) points and (1.32±0.82) points respectively， which were all significantly lower than those before treatment and of the control group after treatment (P<0.05). The level of sIL-2R in the observation group after treatment was (2.11±0.76) ng/mL， which was significantly lower than that of the control group (P<0.05) while the level of the IL - 2 and IFN-γ were (28.14±2.37) pg/mL and (28.04±11.06) pg/mL， which were both significantly higher than those of the control groups (P<0.05). The adverse reaction rate between the two groups had no significant difference (P< 0.05). Conclusion： The compound glycyrrhizin glucoside combined with the Paeonol ointment could significantly improve the symptom scores in patients with ACD， reduce the levels of inflammatory cytokines with few adverse reactions. The curative effect was significantly better than single application of the compound glycyrrhizin glucoside.

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