世界中医药

目的：从生物力学角度探讨Ⅰ型牛胶原蛋白生物膜预防肌腱粘连作用。方法：三黄鸡，3月龄，60只，雌雄各半，体重1.5~2.0 kg，以右足第3趾屈趾深肌腱断裂1/2吻合模型，随机分为假手术组、对照组和Ⅰ型牛胶原蛋白生物膜组，再根据取材时间分为2周组、4周组、6周组、8周组4个亚组，术后2、4、6、8周对吻合端周围粘连程度观察和对包括患侧及健侧第3趾关节屈曲角度、肌腱滑动距离、肌腱最大抗断裂负荷的生物力学检测。结果：Ⅰ型牛胶原蛋白生物膜在术后2、4、6、8周，与假手术组及对照组比较，粘连程度评分明显优于假手术组及对照组(P<0.05);生物力学指标测定显示，关节屈曲角度、肌腱滑动距离、肌腱最大抗断裂负荷各项指标，实验组均优于对照组(P<0.05)。结论：Ⅰ型牛胶原蛋白生物膜可以减少粘连，提高肌腱生物力学指标，具有一定的预防粘连的作用，是一种有效的预防肌腱粘连的新型生物性材料。

English Summary:

To explore the preventive effect of type Ⅰ bovine collagen membrane on tendon adhesion from the prospective of biomechanics. Methods： Sixty chickens at the age of 3 months， half male and half female， weighing 1.5 to 2.0 kg， were made into models with 1/2 deep tendon rupture on the third toe of the right foot. They were randomly divided into sham group， control group and type Ⅰ bovine collagen membrane group. Then four subgroups were divided according to time， including 2 w group， 4 w group， 6 w group， 8 w group. The degree of anastomosis adhesion， the toe joint angle， sliding tendons buckling distance， and tendon rupture of the biggest load were detected. Results： Two， four， six， and eight weeks after the surgery， type Ⅰ bovine collagen membrane group had better results in adhesion score compared with control group (P<0.05); the degree of anastomosis adhesion， the toe joint angle， sliding tendons buckling distance， and tendon rupture of the biggest load were better in the treatment groups (P<0.05). Conclusion： Type Ⅰ bovine collagen membrane can reduce adhesion， improve the tendon biomechanics index， and has a certain preventive adhesion effect， which is a kind of new biological material to effectively prevent tendon adhesion.

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