To observe the clinical efficacy of retention enema of Angang mixture in treating anal cryptitis. Methods： Sixty patients were selected in accordance with the diagnosis criteria and randomly divided into experimental group (n=30) and control group (n=30). Experimental group applied Angang mixture retention enema treatment with anus perfusion apparatus. Control group gave patients Fufang Huangbai Ye retention enema treatment with anus perfusion apparatus. Treatment results were observed and assessed. Results： The clinical studies show that under the same conditions of patients and perfusion apparatus，the clinical efficacy of experimental group was not significantly different from that of the control group (P>0.05). Conclusion： The clinical efficacy of aretention enema treatment of Angang mixture on anal cryptitis with anus perfusion apparatus has significant therapeutic effect. The method has the advantages of convenient use，simple operation，sufficient drug source，low prices. And patients can operate by themselves，so it can be promoted easily. It provides patients with more extensive drug-use methods and ways，and shows the features of TCM. In addition，it has a strong practical value.