To observe the therapeutic effect of Alprostadil injection combined with Bailing capsule on patients with acute kidney injury and explore its mechanism of action.Methods： Four hundred and thirty six cases of acute kidney injury were randomly divided into alprostadil group，bailing capsule group，combined treatment group. Except from the routine treatment，patients in the three groups were respectively given Alprostadil Injection，bailing capsule and the combined treatment for 4 weeks. The levels of urinary albumin excretion rate，serum creatinine，urea，cystatin C before and after treatment were measured. Results： Compared with the only application of Alprostadil injection or corbrin capsule，the combination therapy further decreased the levels of the urinary albumin excretion rate，creatinine，urea，Cystatin C (P<0.05). Conclusion： Alprostadil injection combined with Bailing capsule is effective for acute kidney injury is reliable，and has stronger renal protective effect than the single use of one drug.