To investigate the effects of songlingxuemaikang capsule in the treatment of climacteric syndrome. Methods： One hundred and forty six patients with climacteric syndrome treated in our hospital from October 2010 to October 2012 were randomly divided into study group (n=73) and control group (n=73). All patients were given oryzanol 10 to 20 mg per time，2 to 3 times per day as well as Diethylstilbestrol tablets 0.25 to 1mg per time，once a day，continuously for 3 weeks followed by 1 week of withdrawal. All patients took medicine for 2 consecutive months. Patients in the study group were meanwhile given oral administration of Songlinxuemaikang capsules (3 pills per time，three times a day). Results： After treatment，the total effective rate of control group and study group were 82.2% and 93.2%. Compared with what it was before treatment，follicle-stimulating hormone levels of the two groups were decreased，and the difference was significant (P<0.05); Luteinizing hormone levels and blood estradiol levels of two groups after treatment had been significantly improved，and there was significant different between the two groups (P< 0.05).The somatic symptoms，depressive symptoms and anxiety symptoms were better improved in the study group，and there was significant different between the two groups (P< 0.05). Conclusion： Songlingxuemaikang capsule can significantly improve a variety of clinical symptoms of climacteric syndrome，and it can be routinely applied in the community and the primary hospital.