To observe the short term effects of Rho-kinase inhibitor and Qiliqiangxin capsules on serum tumor necrosis factor-alpha(TNF-α)and interleukin-6(IL-6)levels in patients with chronic heart failure，and explore the mechanism.Methods：120 chronic heart failure patients received conventional treatment for 4 weeks were divided into blank control group (30 cases)（Group A），Rho-kinase inhibitor-treated group (30 cases)（Group B），Qiliqiangxin capsules-treated group(30 cases)（Group C），and the other 30 cases in the treatment with Rho-kinase inhibitor combined with Qiliqiangxin capsules（GroupD）.TNF-α，IL-6 and cardiac function evaluated by BNP were measured before and after treatment.The difference between the 4 groups was analyzed.Results：The baseline of TNF-α，IL-6 and cardiac function was not significantly different in 4 groups (P>0.05).TNF-α and IL-6 levels in Rho-kinase inhibitor combined with Qiliqiangxin capsules（GroupD）were significantly lower than other groups after 4 weeks’ treatment (P<0.05).Conclusion：Rho-kinase inhibitor combined with Qiliqiangxin capsules can improve cardiac function，reduces levels of serum cytokines associated with chronic heart failure.