| 引用本文:郑洁莉 徐 莉.多囊卵巢综合征中医证型与糖代谢及IGF-I、IGFBP-1相关性的研究[J].世界中医药,2014,9(07):. |
|
| 多囊卵巢综合征中医证型与糖代谢及IGF-I、IGFBP-1相关性的研究 |
| Study on the Relationship between TCM Differentiation Types of Polycystic Ovary Syndrome and Glycometabolism， IGF-I and IGFBP-1 |
| 投稿时间：2014-01-17 |
| DOI：10.3969/j.issn.1673-7202.2014.07.017 |
| 中文关键词: 多囊卵巢综合征 中医证型 胰岛素抵抗 |
| English Keywords:Polycystic ovary syndrome TCM differentiation Insulin resistance |
| 基金项目:广东省中医药局课题(项目编号：20130601；项目名称：健康指导配合中药对肥胖型PCOS患者胰岛素生长因子-I、胰岛素生长因子结合球蛋白-I的影响) |
|
| 摘要点击次数: 1281 |
| 全文下载次数: 1537 |
| 中文摘要: |
| 目的：拟探讨多囊卵巢综合征(PCOS)患者中医证型分布规律及与糖代谢、炎性因子IGF-I、IGFBP-1的关系。方法：对120例PCOS患者进行中医证候调查，同时检测患者BMI、胰岛素抵抗稳态模式评估及胰岛素生长因子-I(IGF-I)、胰岛素生长因子结合球蛋白-1(IGFBP-1)水平。并探讨中医证型与糖代谢异常、IGF-I、IGFBP-1的关系。结果：临床辨证分为肾虚、脾虚痰湿、肝郁气滞，构成比分别为35%，33%，32%。各证型间比较P>0.05，差异无统计学意义。脾虚痰湿组BMI、FINS、Homa-IR，P均<0.05，差异具有统计学意义，脾虚痰湿组IGFBP-I较肾虚、肝郁气滞组下降，P均<0.05，差异具有统计学意义，脾虚痰湿组IGF-I与肾虚、肝郁气滞组高比较升高，差异无统计学意义(P>0.05)。结论：PCOS中医证型以肾虚、脾虚痰湿、肝郁气滞为主，脾虚痰湿证与胰岛素抵抗、IGFBP-I下降有关。 |
| English Summary: |
| To investigate the regularities of distribution of TCM differentiation types of polycystic ovary syndrome， and its relationship with glycometabolism and inflammatory factors IGF-I and IGFBP-1. Methods： The TCM differentiation types of 120 cases of PCOS patients was investigated， and at the same time their BMI， homeostasis model assessment insulin resistance and insulin growth factor-I (IGF-I)， insulin like growth factor binding immunoglobulin-1 (IGFBP-1) of patients were measured. The relationship between the TCM differentiation of polycystic ovary syndrome and glycometabolism， IGF-I and IGFBP-1 were explored. Results： TCM differentiation types included kidney deficiency， phlegm-dampness due to deficiency of the spleen， stagnation of liver qi， and the constituent ratio was 35%， 33%， and 32%. The difference in all the three groups was not significant， P>0.05. The levels of BMI， FINS， Homa-IR of phlegm-dampness due to deficiency of the spleen were higher than those of the other two groups， and the differences remained significant， P<0.05. The level of IGFBP-I of phlegm-dampness due to deficiency of the spleen was lower than that of the other two， and the differences remained significant， P<0.05. The level of IGF-I phlegm-dampness due to deficiency of the spleen was higher than that of the other two， and the difference was not significant， P>0.05. Conclusion： The TCM differentiation types of polycystic ovary syndrome mainly included kidney deficiency， phlegm-dampness due to deficiency of the spleen， stagnation of liver qi. The syndrome of phlegm-dampness due to spleen deficiency was relevant to insulin resistance and decline of IGFBP-1. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
