| 引用本文:李 颖 张纾难.肺痿冲剂治疗肺间质纤维化疗效观察及对肿瘤标记物CA19-9的影响[J].世界中医药,2014,9(08):. |
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| 肺痿冲剂治疗肺间质纤维化疗效观察及对肿瘤标记物CA19-9的影响 |
| Observation on Feiwei Medicinal Instant Granules on Pulmonary Interstitial Fibrosis and Its Effect on Tumor Markers of CA19-9 |
| 投稿时间：2014-07-24 |
| DOI：10.3969/j.issn.1673-7202.2014.08.006 |
| 中文关键词: 肺间质纤维化 益气活血 肺痿方 肿瘤标记物CA19-9 临床疗效 |
| English Keywords:Pulmonary interstitial fibrosis Benefiting vital energy and activating blood circulation Feiwei medicinal instant granules Clinical curative effect Tumor markers of CA19-9 |
| 基金项目:国家中医药管理局中医药行业科研专项（编号：200807046） |
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| 中文摘要: |
| 目的：观察肺痿冲剂治疗肺间质纤维化的临床疗效及对肿瘤标记物CA19-9的影响。方法：将120例肺间质纤维化患者随机分为治疗组61例、对照组59例，2组患者均进行基础治疗，治疗组同时给予肺痿冲剂方每次100 mL，每日2次口服；对照组给予泼尼松每次30 mg，每日1次口服。治疗2个月后评价2组患者中医证候疗效及患者满意度，并观察2组患者治疗前后中医证候积分、呼吸困难评分、6分钟步行试验、肺功能［包括肺总量(TLC)、用力肺活量（FVC)、一秒用力呼气容积（FEV1）、FEV1/FVC、一氧化碳弥散量(DLCO)］及肿瘤标记物CA19-9的变化。结果：治疗组与对照组中医证候总有效率分别为62.3%、32.2%，2组比较差异有统计学意义（P<0.01）。治疗后治疗组中医证候积分、呼吸困难评分、6分钟步行试验、肺功能TLC、FEV1及肿瘤标记物CA19-9均较治疗前改善（P<0.05或P<0.01）；对照组中医证候部分指标积分、呼吸困难评分较治疗前改善（P<0.05或P<0.01），但肺功能FVC反而较治疗前恶化（P<0.05）。治疗后治疗组与对照组比较，中医证候部分指标积分、生活质量部分指标评分、6分钟步行试验、肺功能FVC及肿瘤标记物CA19-9差异有统计学意义（P<0.05或P<0.01），治疗组疗效优于对照组。结论：肺痿冲剂方治疗肺间质纤维化可减轻患者呼吸困难症状，改善患者生活质量、肺功能。并提示了肺痿冲剂可能有抑制IPF上皮细胞的凋亡及异常增生的作用。 |
| English Summary: |
| To observe the curative effect of the Feiwei medicinal instant granules on pulmonary interstitial fibrosis and effect on tumor markers of CA19-9.Methods：One hundred and twenty patients with pulmonary interstitial fibrosis were randomly divided into treatment group (n=61) and control group (n=59)，and all of them were given fundamental treatment.Patients in the treatment group also received oral administration of Feiwei medicinal instant granules for consumptive lung disease twice a day，100ml a time.Patients in the control group were given oral administration of prednisone once a day，30mg each time.After 2 months of treatment，a series of changes of the two groups before and after the treatment，including：TCM score，dyspnea scores，six-minutes walking test，TLC，FVC，FEV1，FEV1/FVC，DLCO and tumor markers of CA19-9 were observed.Results：The total effective rates of TCM syndrome in treatment group and control group were respectively 61.7% and 34.8%，and there was significant difference between the two groups.In the treatment group，TCM score，dyspnea scores，six-minutes walking test，TLC，FEV1，and tumor markers of CA19-9 were improved obviously（P<0.05 or P<0.01）.In the control group，the part of TCM score，dyspnea scores were relatively improved，too（P<0.05）.However，the treatment group was superior to control group in the improvement of TCM syndromes，dyspnea scores，six-minutes walking test，FVC and tumor markers of CA19-9.Conclusion：Feiwei medicinal instant granules can effectively relieve the symptoms of dyspnea in patients with pulmonary interstitial fibrosis，increase exercise tolerance，enhance the TLC，FEV1 in lung function，and bring patients more satisfaction.The medicinal instant granules may inhibit apoptosis of epithelial cells of IPF and abnormal proliferation. |
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