| 引用本文:王 涛.丹红注射液对下肢骨折患者凝血及局部微循环状态的影响研究[J].世界中医药,2014,9(08):. |
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| 丹红注射液对下肢骨折患者凝血及局部微循环状态的影响研究 |
| Study on Influence of Danhong Injection on the Coagulation and Local Microcirculation of Patients with Lower Extremity Fractures |
| 投稿时间：2014-03-26 |
| DOI：10.3969/j.issn.1673-7202.2014.08.015 |
| 中文关键词: 下肢骨折 丹红注射液 凝血功能 微循环 |
| English Keywords:Lower extremity fractures Danhong injection Coagulation Microcirculation |
| 基金项目:四川省雅安市中医药卫生基金项目(编号：201828292) |
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| 中文摘要: |
| 目的：探讨丹红注射液对下肢骨折患者凝血功能和局部微循环状态的影响。方法：将2012年9月至2013年2月期间本院收诊的下肢骨折患者随机分成2组，对照组和治疗组各72例。所有患者均采用手术内固定治疗骨折，治疗组患者术后静脉滴注丹红注射液，40 mL(次·d)，连续给药2周。比较治疗前后2组患者间骨代谢指标、凝血功能指标及微循环相关指标差异。结果：治疗7、28 d后，治疗组骨碱性磷酸酶(Bone Alkaline Phosphatase，BALP)比例和血清碱性磷酸酶(Alkaline Phosphatase，BGP)、I型前胶原羧基端肽(Procollagen Carboxyl Terminal Peptide，PICP)浓度显著高于对照组，内皮素(Endothelin，ET)和血清C反应蛋白(C Reactive Protein，CRP)水平显著低于对照组;治疗组患者凝血酶时间(Thrombin Time，TT)、凝血酶原时间(Prothrombin Time，PT)、活化部分凝血活酶时间(Activated Partial Thromboplastin Time，APTT)、纤维蛋白原(Fibrinogen，Fb)显著长于对照组;治疗组患者甲襞微循环指标形态积分、流态积分、周围状态积分和总积分显著低于对照组，毛细血管流速显著快于对照组，而白微栓则显著低于对照组(P<0.05)。结论：丹红注射液有助于下肢骨折患者凝血功能和微循环障碍的改善，有利于患者的骨骼愈合。 |
| English Summary: |
| To observe the influence of Danhong injection on the coagulation and local microcirculation of patients with lower extremity fractures.Methods：Patients with lower extremity fractures treated in our hospital from September 2012 to February 2013 were randomly divided into control group (n=72) and observation group (n=72).All the patients were treated with internal fixation treatment，and patients in observation group were also treated with danhong injection，40ml/time/day，for 2 weeks.Then the indexes of bone metabolism，coagulation and local microcirculation of two groups were compared.Results：After 7，28 days of treatment，the serum levels of BALP，BGP and PICP of observation group were all higher than those of the control group; the ET and CRP were lower than those of control group; and the TT，PT，APTT，Fb of observation group were significantly shorter than those of the control group; the indexes of nailfold microcirculation such as form integral，flow state integral，points around the state and total integral of observation group were all significantly lower than those of the control group; the capillary flow rate was much faster in observation group; white micro-bolt of the observation group was lower than that of control group，all P<0.05.Conclusion：Danhong injection can effectively improve the coagulation and local microcirculation of patients with lower extremity fractures，and benefit the patients bone healing. |
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