Depression is a kind of syndrome whose significant characteristic is bad mood lasting for a long time. The morbidity of depression is increased year by year. Therefore, depression is called as "epidemic disease in the twentieth century”. Professor Nie Huimin is an veteran and famous doctor in Traditional Chinese Medicine. She is also the tutor of the second, third, fourth term national inheritor of traditional Chinese medicine. Professor Nie Huimin is good at using the classic formulas to treat miscellaneous disease. The academic successors of Professor Nie Huimin summarized her experiences of treating depression by statistical analysis. The results show that Professor Nie Huimin treats depression by regulating the function of heart and liver and applies the method of dispelling melancholy and relieving uneasiness of mind and body tranquilization. The formulas chosen by Professor Nie Hui-min to treat the depression is the combination of radix bupleuri added oyster and keel prescription and jujube kernel prescription. The herbs chosen by Professor Nie Huimin to treat the depression are jujube kernel, radix bupleuri, radix scutellariae, raw keel, raw oysters and so on.