To explore the value of cellular level pulverizing technology used in cataplasm. Methods： Common fine and ultrafine powder poultice were prepared, and the different sizes of cataplasma puhuang psorhamnetin-3-O-neohesperidin transdermal absorption were comparatively analyzed. Results： The permeation rate of isorhamnetin-3-O-neohesperidin in ultrafine powder cataplasma was significantly higher than that in ordinary poultice (P<0.05).Conclusion： Cellular level pulverizing technology used in Chinese medicine preparations can help to improve the quality and bioavailability of drugs, optimize the production processes of Chinese medicine preparations and reduce drugs profligacy, and hence it deserves further application.