| 引用本文:唐光钰 唐今尧.糖肾康煎剂与羟苯磺酸钙联合黄芪疏血通治疗糖尿病肾病IV期48例的临床观察[J].世界中医药,2014,9(09):. |
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| 糖肾康煎剂与羟苯磺酸钙联合黄芪疏血通治疗糖尿病肾病IV期48例的临床观察 |
| Clinical observation on Integrated Therapy of Tangshenkang Decoction, Calcium Dobesilate Combined with Astragalus Shuxuetong Treating 48 Cases of Phase IV Diabetic Nephropathy |
| 投稿时间：2013-09-13 |
| DOI：10.3969/j.issn.1673-7202.2014.09.015 |
| 中文关键词: 糖肾康煎剂 羟苯磺酸钙 黄芪/疏血通注射液 糖尿病肾病 |
| English Keywords:Tangshenkang decoction of calcium dobesilate Astragalus Shuxuetong injection Diabetic nephropathy |
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| 中文摘要: |
| 目的：观察糖肾康煎剂与羟苯磺酸钙分散片联合黄芪及疏血通注射液治疗糖尿病肾脏疾病IV期的临床疗效。方法：选取确诊的糖尿病肾脏疾病IV期患者96例，随机分为对照组和治疗组各48例。2组均给予胰岛素控制血糖，替米沙坦和硝苯地平缓释片控制血压，黄芪注射液和疏血通注射液静脉滴注，治疗组加用羟苯磺酸钙分散片和糖肾康煎剂口服。病程均为14 d。观察治疗前后临床症状、24 h尿白蛋白定量、血脂和肾功能等指标的变化。结果：2组治疗后较治疗前各项检验指标及临床症状评分均有不同程度下降，但治疗组治疗后临床疗效总有效率为93.75%，对照组总有效率为68.8%，组间比较有统计学意义(P<0.05)。临床主要症状评分2组治疗后较治疗前虽均有改善，但对照组改善不明显(P>0.05)，治疗组改善明显(P<0.05)，治疗组优于对照组(P<0.05)。24 h尿蛋白定量、TC、TG、BUN、Scr等主要生化指标2组治疗后较治疗前均有不同程度降低，但治疗组显著下降(P<0.05)，对照组下降不显著(P>0.05)，2组比较差异有统计学意义(P<0.05)。结论：糖肾康煎剂与羟苯磺酸钙分散片联合黄芪及疏血通注射液治疗糖尿病肾病IV期临床疗效确切。特别是改善临床症状，减少尿蛋白排泄，改善肾脏微循环，促进肾血流，恢复肾功能，从而达到有效阻断或逆转病程进展速度，为糖尿病肾病优化组合治疗方案开辟了一条新途径。 |
| English Summary: |
| To observe the clinical effect of Tangshenkang decoction combined with calcium dobesilate dispersible tablets and Astragalus and Shuxuetong injection in treatment of phase IV diabetic nephropathy.Methods：Ninety six patients with phase IV diabetic renal disease were randomly divided into control group (n=48) and treatment group (n=48). Patients in both groups were given insulin to control blood sugar, telmisartan and nifedipine tablets to control blood pressure, as well as astragalus injection and Shuxuetong injection. Besides, patients in the treatment group were given dispersible tablets and Tangshenkang decoction with calcium dobesilate. The treatment course was 14 days. The changes of clinical symptoms, 24 h urinary albumin excretion, blood lipid and renal function were observed before and after treatment.Results：All indexes and clinical symptom score of patients in both groups after treatment were decreased. The total effective rate of treatment group was 93.75%, while that of the control group was 68.8%, and the difference between the two groups was significant (P<0.05). The main clinical symptom score of patients in both groups were improved after treatment, but the control group had no obvious improvement (P>0.05), while the treatment group showed significant improvement (P<0.05). The main biochemical index of 24 h urinary protein, TC, TG, BUN, Scr were reduced to various degrees after treatment, and the treatment group decreased significantly (P<0.05), while the decrease in the control group was not significant (P>0.05), so there was significant difference between the two groups (P<0.05).Conclusion：Tangshenkang decoction combined with calcium dobesilate dispersed tablets and Astragalus shows definite clinical efficacy in the treatment of phase IV diabetic nephropathy. The therapy can improve clinical symptoms, reduce urinary protein excretion, improve renal microcirculation, promote the recovery of renal function, promote renal blood flow, so as to effectively block or reverse the disease progression, open up a new way for the optimization and combination therapy of diabetic nephropathy. |
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