To investigate clinical efficacy and action mechanism of Penyanping formulal combined with Traditional Chinese Medicine (TCM) retention enema for damp-heat type of chronic pelvic inflammatory disease.Methods：One hundred and twenty patients with damp-heat type of chronic pelvic inflammatory disease were randomly divided into treatment group (n=60) and control group (n=60). Patients in the control group received fibrauretine tablets with Kurarinone anus suppository treatment, while patients in the treatment group were treated with Penyanpng formula combined with TCM retention enema. The clinical efficacy and hemorheology between the two groups were compared before and after treatment.Results：The effective rate of the treatment group was 91.67% , which was significantly higher than the 76.67% of the control group (P<0.05). After treatment, the high shear whole blood viscosity, low shear whole blood viscosity and plasma viscosity of patients in the treatment group were (2.12±0.21) mPa·s, (7.20±1.72) mPa·s and (1.12±0.13) mPa·s , which were significantly lower than the states before the treatment and those of the control groups, and the differences were statistically significant (P<0.05).Conclusion：Oral administration of Penyanping formula with TCM retention enema for damp-heat type of chronic pelvic inflammatory disease has significant effect. It can effectively improve the clinical symptoms and has better clinical value.