| 引用本文:王 芳1，2 薛 杨1，2 杨静玉1，2 王 欢1，2 吴春福1，2.苹果多酚对卡介苗联合脂多糖所致小鼠免疫性肝损伤的保护作用[J].世界中医药,2014,9(09):. |
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| 苹果多酚对卡介苗联合脂多糖所致小鼠免疫性肝损伤的保护作用 |
| Hepatoprotective Role of Apple Polyphenols against Immunological Liver Injury in Mice |
| 投稿时间：2013-11-12 |
| DOI：10.3969/j.issn.1673-7202.2014.09.029 |
| 中文关键词: 苹果多酚 卡介苗 脂多糖 免疫性肝损伤 |
| English Keywords:Apple polyphenols Bacillus Calmette-Guerin Lipopolysaccharide Immunological liver injury |
| 基金项目:沈阳市科学技术项目计划资助（编号：F13-318-1-20） |
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| 中文摘要: |
| 目的：观察苹果多酚（Apple Polyphenols，AP）对小鼠免疫性肝损伤的保护作用。方法：采用卡介苗联合脂多糖制备小鼠免疫性肝损伤模型。研究AP对小鼠肝指数和脾指数，血清中谷草转氨酶（Aspartate Transaminase，AST）和谷丙转氨酶（Alanine Transaminase，ALT）活性，血清总蛋白（Total Protein，TP），白蛋白（Albumin，Alb）和白蛋白/球蛋白（A/G）含量的改善作用，同时采用HE染色方法观察AP对免疫性肝损伤小鼠肝脏病理改变的保护作用。结果：AP能明显抑制免疫性肝损伤模型小鼠异常升高的肝指数和脾指数，降低血清中AST活性，不同程度地升高血清中TP和Alb的含量，同时对肝组织病理异常变化也有显著的改善作用。结论：AP对卡介苗联合脂多糖所致的小鼠免疫性肝损伤具有保护作用。 |
| English Summary: |
| To observe hepatoprotective role of apple polyphenols (AP, Appjfnol) on immunological liver injury in mice.Methods： An immunological liver injury model in mice was established by intravenous injection of Bacillus Calmette-Guerin (BCG) and lipopolysaccharide (LPS). The liver index and spleen index, the activities of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), the levels of serum total protein (TP), albumin (Alb) and albumin/globulin (A/G) were detected. Histopathologic change was also investigated by HE staining. Results： AP inhibited the increases of liver index and spleen index, prevented the increase of serum AST activity and the decrease of serum TP and Alb levels. Histopathological abnormalities were also improved after AP administration. Conclusion： AP played a significant hepatoprotective role against BCG and LPS induced immunological liver injury in mice. |
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