Heart and Brain are both physiologically and pathologically connected in either Chinese Medicine or Western Medicine perspective. In the holistic point of view of Chinese Medicine, Shenfu Decoction can not only rescue the depletion of heart yang qi, but also be applicable to ischemic brain injury due to yang qi deficiency. Modern pharmacology research finds that Ginsen and Aconite possess multiple function on various kinds of cardiac and cerebral diseases which support our theory of the Shenfu Decoction provides synchronized treatment on heart and brain with qi repleshing and yang rescuing.