To observe the clinical efficacy of the Clopidogrel Bisulfate tablets combined with Atorvastatin Calcium capsules and Yangxinshi tablets on angina pectoris patients after PCI.Methods: Seventy eight patients were randomly divided into the treatment group (n=39) and the control group (n=39). Patients in the treatment group were given Clopidogrel Bisulfate tablets combined with Atorvastatin Calcium capsules and Yangxinshi tablets, and the control group applied Simvastatin tablets combined with Aspirin Enteric-coated tablets. The therapeutic effects of the two groups were evaluated after 12 weeks of treatment. The relevant indicators levels were measured, such as TC, TG, HDL-C and LDL-C. Results: The effective rates of the treatment group and control group were 93.31% and 74.36% (P<0.01). The levels of TG and TC and LDL-C, were significantly lower after treatment in both two groups, while the level of HDL-C was significantly increased in treatment group. Conclusion: The combination therapy of Clopidogrel Bisulfate tablets, Atorvastatin Calcium capsules and Yangxinshi tablets is an available drug combination for the treatment of angina pectoris after PCI, and it can effectively reduce the incidence of cardiovascular events.