| 引用本文:刘俊波 黄常江 廖天华 莫春明 韦赤勇.益气清肺汤联合化疗治疗老年晚期非小细胞肺癌对患者生活质量的影响[J].世界中医药,2014,9(10):. |
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| 益气清肺汤联合化疗治疗老年晚期非小细胞肺癌对患者生活质量的影响 |
| Effects of Yiqi Qingfei Decoction Combined with Chemotherapy on Life Quality of Elderly Patients with Late Stage of Non-Small Cell Lung Cancer |
| 投稿时间：2013-09-08 |
| DOI：10.3969/j.issn.1673-7202.2014.10.014 |
| 中文关键词: 非小细胞肺癌 益气清肺汤 化疗疗法 生活质量 |
| English Keywords:Non-small cell lung cancer Yiqi Qingfei decoction Chemotherapy Life quality |
| 基金项目:广西贵港市科学研究与技术开发计划项目课题（编号：贵科攻1105006） |
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| 中文摘要: |
| 目的：观察益气清肺汤联合化疗治疗老年晚期非小细胞肺癌对患者生活质量的影响。方法：将63例患者随机分为治疗组33例与对照组30例，2组均采用相同化疗方案治疗；21 d为1个周期，2个周期评价疗效。治疗组在化疗前2 d加用益气清肺汤治疗。观察2组治疗后中医临床证候变化、治疗前后生活质量量表EORTC-QLQ-SF-36调查问卷评价及不良反应。结果：2组中医临床证候变化比较，治疗组与对照组总改善率分别为84.8%和60.0%（P<0.05）；2组治疗前后生活质量量表EORTC-QLQ-SF-36调查问卷评分比较，治疗组躯体功能、角色功能、情绪功能、物理症状及整体健康状况均优于对照组，差异有统计学意义（P<0.05）；而认知功能、社会功能差异无统计学意义（P>0.05）。2组不良反应比较，治疗组低于对照组（P>0.05）。结论：益气清肺汤联合化疗治疗老年晚期非小细胞肺癌具有改善中医临床证候，减轻不良反应，提高生活质量，延长生存期。 |
| English Summary: |
| To observe the impacts of yiqi qingfei decoction combined with chemotherapy on life quality of the elderly patients with late stage of non-small cell lung cancer (NSCLC).Methods:Sixty-three patients were randomly divided into treatment group (n=33) and control group (n=30). Patients in both groups were given chemotherapy, and one treatment course was 21 day. Evaluations were given after 2 treatment courses. Patients in the treatment group were given Yiqi Qingfei decoction 2 days before the chemotherapy. The change of TCM clinical syndromes, the evaluation and adverse reactions, as well as quality of life questionnaire EORTC-QLQ-SF-36 were observed before and after treatment among patients in both groups.Results:In terms of the change of TCM clinical syndromes, the total improvement rates of the treatment group and the control group were respectively 84.8% and 60.0% （P<0.05）. As for the quality of life scale EORTC-QLQ-SF-36 questionnaire scores of patients in the two groups after treatment, the physical function, role function, emotional function, physical symptoms and overall health status of patients in treatment group were all better than those of the control group（P<0.05）.There was no significant difference in terms of the cognitive function and social function between the two groups（P>0.05）.The incidence of the adverse reactions in the treatment group was lower than that of the control group（P>0.05）.Conclusion:The combined therapy of Yiqi Qingfei decoction and chemotherapy treating elderly patients with non-small cell lung cancer at the late stage can improve TCM clinical syndromes, reduce adverse reactions, improve quality of life and prolong survival. |
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