To observe the impacts of yiqi qingfei decoction combined with chemotherapy on life quality of the elderly patients with late stage of non-small cell lung cancer (NSCLC).Methods:Sixty-three patients were randomly divided into treatment group (n=33) and control group (n=30). Patients in both groups were given chemotherapy, and one treatment course was 21 day. Evaluations were given after 2 treatment courses. Patients in the treatment group were given Yiqi Qingfei decoction 2 days before the chemotherapy. The change of TCM clinical syndromes, the evaluation and adverse reactions, as well as quality of life questionnaire EORTC-QLQ-SF-36 were observed before and after treatment among patients in both groups.Results:In terms of the change of TCM clinical syndromes, the total improvement rates of the treatment group and the control group were respectively 84.8% and 60.0% （P<0.05）. As for the quality of life scale EORTC-QLQ-SF-36 questionnaire scores of patients in the two groups after treatment, the physical function, role function, emotional function, physical symptoms and overall health status of patients in treatment group were all better than those of the control group（P<0.05）.There was no significant difference in terms of the cognitive function and social function between the two groups（P>0.05）.The incidence of the adverse reactions in the treatment group was lower than that of the control group（P>0.05）.Conclusion:The combined therapy of Yiqi Qingfei decoction and chemotherapy treating elderly patients with non-small cell lung cancer at the late stage can improve TCM clinical syndromes, reduce adverse reactions, improve quality of life and prolong survival.