To observe the efficacy of Xiandan Shengxue granules on the treatment of idiopathic thrombocytopenic purpura. Methods： One hundred and twenty three patients with idiopathic thrombocytopenic purpura were randomly divided into treatment group (n=63) and control group (n=60). Patients in the control group were given Weixuening granules, and the treatment group applied Xiandan Shengxue granules. The course of treatment was 4 weeks. The changes of purple, god fatigue, five upset hot, dry mouth, bleeding, platelet count were observed. Results： The excellence rate of treatment was 84.13%, and its total effective rate was 96.83%; the excellence rate of the control group was 85.00%, and the total effective rate was 95.00%. There was no significant difference between groups. For idiopathic thrombocytopenic purpura caused by traditional Chinese medicine syndrome, the excellence rate of treatment group was 71.43%, and total effective rate was 95.24%; and excellence rate of the control group was 66.67%, and the total effective rate was 95.00%, there was no significant difference which meant similar curative effect between the two groups. Conclusion： The Xiandan Shengxue granules treating idiopathic thrombocytopenic purpura have good curative effect.