To investigate the seasonal rhythm of the serum IgE and eosnophils of patients with rhinallergosis,and further verify the coherence between the seasonal susceptibility of rhinallergosis and one of traditional Chinese medicine (TCM) visceral manifestation theory of “mutual correspondence of heaven and human” so as to provide the essential evidence for prevention rhinallergosis.Methods:Forty healthy people and forty rhinallergosis patients were selected.The serum of 80 cases was collected separately in spring and winter.All of blood samples were divided into four groups,including control group in spring (CS),control group in winter(CW),rhinallergosis group in spring(RS) and rhinallergosis group in winter(RW).Eosnophils were counted by Automatic biochemistry analyzer,IgE were detected by radioimmunoassay.Results:The levels of IgE in RS and RW were much higher than those in CS and CW.The count of eosnophils in RS and RW increased significantly compared with those in CS and CW.There was positive correlation between IgE and eosnophils.Conclusion:The seasonal rhythm of serum IgE and eosnophils embodies positive correspondence between people and nature which is one of traditional Chinese medicine theories.The research provides the important guideline of prevention and treatment rhinallergosis.