To observe the clinical efficacy of Fuzhenghuatan formula combined with GP chemotherapy regimens in treating advanced non-small cell lung cancer.Methods:Sixty patients with advanced non-small cell lung cancer were randomly divided into two groups,the control group (chemotherapy group,n=30) and the treatment group (chemotherapy + FuZhengHuaTan herbs group,n=30).After the treatment of two months,the changes of indices including fatigues,TCM syndromes,physical conditions and chemotherapy side effects were observed.Results:Compared with the control group,the treatment with Fuzhenghuatan herbs and chemotherapy could significantly reduce the total FSI score (P<0.05),and TCM syndromes such as cough,bloody sputum,fever,chest pain,short breath,fatigue were better alleviated (P<0.05),and KPS score in the treatment group was significantly higher (P<0.05); in addition,the treatment group also had obvious advantages in reducing white blood cells,platelets,nausea,vomiting,and chemotherapy neurotoxicity (P<0.05).Conclusion:Fuzhenghuatan herbs treating advanced non-small cell lung cancer patients can relieve fatigue and improve TCM syndromes,enhance quality of life and reduce the side effects of chemotherapy.