世界中医药

目的：观察扶正化痰方联合GP方案治疗中晚期非小细胞肺癌的临床疗效。方法：60例中晚期非小细胞肺癌随机分为2组，对照组（单纯化疗组）、治疗组（化疗+扶正化痰方组）各30例，治疗2个月后，观察2组疲劳程度、中医证候、体力状况、化疗不良反应等变化情况。结果：同对照组相比，治疗组能够明显降低患者的FSI总得分（P<0.05），在咳嗽、血痰、发热、胸痛、短气、乏力等中医证候的缓解及改善方面明显优于对照组（P<0.05），KPS评分治疗组明显高于对照组（P<0.05），另外，治疗组在减轻白细胞、血小板下降、恶心、呕吐以及避免神经毒性等化疗不良反应方面也具有明显优势（P<0.05）。结论：扶正化痰方对于中晚期非小细胞肺癌具有缓解患者疲劳症状、改善中医证候、提高生活质量及减轻化疗不良反应的作用。

English Summary:

To observe the clinical efficacy of Fuzhenghuatan formula combined with GP chemotherapy regimens in treating advanced non-small cell lung cancer.Methods:Sixty patients with advanced non-small cell lung cancer were randomly divided into two groups,the control group (chemotherapy group,n=30) and the treatment group (chemotherapy + FuZhengHuaTan herbs group,n=30).After the treatment of two months,the changes of indices including fatigues,TCM syndromes,physical conditions and chemotherapy side effects were observed.Results:Compared with the control group,the treatment with Fuzhenghuatan herbs and chemotherapy could significantly reduce the total FSI score (P<0.05),and TCM syndromes such as cough,bloody sputum,fever,chest pain,short breath,fatigue were better alleviated (P<0.05),and KPS score in the treatment group was significantly higher (P<0.05); in addition,the treatment group also had obvious advantages in reducing white blood cells,platelets,nausea,vomiting,and chemotherapy neurotoxicity (P<0.05).Conclusion:Fuzhenghuatan herbs treating advanced non-small cell lung cancer patients can relieve fatigue and improve TCM syndromes,enhance quality of life and reduce the side effects of chemotherapy.

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