Professor Zeng Qingming holds the view that depression is associated with liver, spleen, kidney, and it is closely related to factors of the deficiency, phlegm, blood stasis, depressive factors. During his many years of experience in clinical practice, the application of Chaihu added to Longgumuli decoction treating depression shows satisfactory curative effect. As for the preparation, he uses decoction at the beginning, then chooses creams, pills, powder, capsules and wine agent. This paper summarizes the typical medical cases of applying Chaihu added to Longgumuli decoction treating depression, so as to verify its effectiveness, analyze how it flexibly use Zhang zhongjings prescription so as to provide a guiding significance.