Osteoarthritis (osteoarthritis, OA) is a senile degenerative joint disease which is clinically characterized by pain, numbness, inconvenient flexion in weight-bearing joints. The disease belongs to the category of arthralgia syndrome. Kidney deficiency is the root cause, and blood stasis is pathological factor. Both of them influence each other throughout the pathological process of osteoarthritis. Niuxijianbu granules of the Guang anmen Hospital are made based on years of experience of famous old herbalist doctors and the achievements of modern pharmacology. Hence, the method of reinforcing the kidney and promoting blood circulation could be considered as the basic way to treat OA with satisfactory clinical effect.