| 引用本文:王林元 陈绍红 屈胜胜 李 伟 黄银峰 张建军.巴西莓对急性酒精中毒小鼠的解酒及保肝作用研究[J].世界中医药,2014,9(10):. |
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| 巴西莓对急性酒精中毒小鼠的解酒及保肝作用研究 |
| The Detoxication and Protective Effect of Acai Against Acute Alcohol Toxication and Acute Alcohol Liver Injury in Mice |
| 投稿时间：2014-06-25 |
| DOI：10.3969/j.issn.1673-7202.2014.10.024 |
| 中文关键词: 巴西莓 酒精中毒 肝损伤 抗氧化 |
| English Keywords:Acai Ethanol Toxication Liver injury Anti-oxidant |
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| 摘要点击次数: 1237 |
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| 中文摘要: |
| 目的:研究巴西莓解酒防醉及对急性酒精性肝损伤的影响。方法:急性酒精中毒实验:小鼠按0.15 mL/10 g灌胃50%乙醇，建立急性酒精中毒动物模型，观察小鼠活动状况，醉酒潜伏期，醒酒时间。急性酒精性肝损伤实验:小鼠按0.12 mL/10 g灌胃50%乙醇，建立小鼠急性酒精性肝损伤模型，观察巴西莓对小鼠肝细胞膜通透性，肝脏脂质过氧化反应等的影响。结果:巴西莓可以延长醉酒潜伏期(P<0.05)，缩短醉酒动物睡眠时间，且可降低血清ALT、AST(P<0.01)，升高肝脏GSH(P<0.05)、SOD水平，降低肝脏MDA、TG含量(P<0.05)，结论:巴西莓具有解酒防醉作用，且对酒精性肝损伤具有一定的保护作用。 |
| English Summary: |
| To study the effects of Acai (Euterpe Oleraceae Mart.) on acute alcohol toxication and protective effect on acute alcohol liver injury in mice.Methods:Acute alcohol toxication animal model was established by alcohol gavaged (50% at 15 mL/kg).The acute liver injury animal model was established by alcohol gavaged (50% at 12 mL/kg).The serum levels of ALT,AST and the content of MDA,TG,the activity of GSH,SOD in liver of the mice were measured.Results:Acai can shorten the recovery time of rightening reflex compared with the model groups (P<0.05).The groups of Acai significantly reduced the levels of serum ALT,AST(P<0.01) which were induced by ethanol,and the content of MDA,TG (P<0.05),the activity of GSH in liver were significantly different compared with those of the model groups (P<0.05).Conclusion:Acai has effect of relieving alcohol toxicity and a protective effect on acute alcohol liver injury in mice and its mechanism may relate to the capacity of anti-oxidant. |
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