To study the effects of Acai (Euterpe Oleraceae Mart.) on acute alcohol toxication and protective effect on acute alcohol liver injury in mice.Methods:Acute alcohol toxication animal model was established by alcohol gavaged (50% at 15 mL/kg).The acute liver injury animal model was established by alcohol gavaged (50% at 12 mL/kg).The serum levels of ALT,AST and the content of MDA,TG,the activity of GSH,SOD in liver of the mice were measured.Results:Acai can shorten the recovery time of rightening reflex compared with the model groups (P<0.05).The groups of Acai significantly reduced the levels of serum ALT,AST(P<0.01) which were induced by ethanol,and the content of MDA,TG (P<0.05),the activity of GSH in liver were significantly different compared with those of the model groups (P<0.05).Conclusion:Acai has effect of relieving alcohol toxicity and a protective effect on acute alcohol liver injury in mice and its mechanism may relate to the capacity of anti-oxidant.