Abstract:To study the content changes of bergenin in Rhizoma Bergeniae Scopulosae before and after stir-baking with bran.Methods:Bergenin content in Rhizoma Bergeniae Scopulosae was determined by HPLC.Chromatographic column:UltisilTM XB-C18 column (150 mm×10 mm,5 μm); moving phase:taking moving phase as carbinol to nater(32∶68);flow velocity:taking flow velocity as 1.0 ml/min; column temperature:taking colum temperature as room tomperature; determine wavelength was 275nm;sample size was 20 μl.Results:Bergenin content in Rhizoma Bergeniae Scopulosae before stir-baking with bran was 16.82 mg/g,and after bran fried was 22.15 mg/g.Conclusion:Bergenin content in Rhizoma Bergeniae Scopulosae after stir-baking with bran is higher than before.So we can see that stir-baking with bran can increase therapeutic effect of Rhizoma Bergeniae Scopulosae.