To analyze the medication law of famous and veteran TCM doctors in treating coronary heart disease with varclus cluster method．Methods： The 336 case records collecting from famous and veteran TCM doctors in treating coronary heart disease was input to the analysis software. The 39 traditional Chinese medicine whose application frequency were over 20 times were analyzed by varclus cluster analysis．Results： There were fourteen kinds of Chinese medicine, namely were: 1.Chenpi, Maidong, Shichangpu, Wuweizi; 2.Chaihu,Chaozaoren, Hongshen, Zhishi; 3.Banxia, Gualou, Xiebai, Zhiqiao; 4.Yuanhu, Yujin, Zhigancao; 5.Baizhu, Guizhi; 6.Chuanxiong, Danggui, Danshen, Gegen; 7.Chishao, Honghua, Sharen, Taoren; 8.Huanglian, Shengdi, Suanzaoren, 9.Baishao, Gancao; 10.Sanqifen, Tanxiang; 11.Fuling, Tinglizi, Zexie; 12.Huangqi, Shuizhi; 13.Dangshen; 14.Yuanzhi. Conclusion： To treat a specific syndrome or symptom of the coronary heart disease, famous and veteran TCM doctors tend to use two or more kinds of traditional Chinese medicine, which was called medicine group. The analysis results has certain guiding significance in clinical practice.