To explore the active monitoring method on the safety of traditional Chinese medicine decoction,and discuss the occurrence characters of the adverse drug reactions(ADR) of decoction containing Coptis.Methods:Patients who were prescribed the Traditional Chinese medicine decoction containing Coptis were interviewed,and the common data and the ADR characteristics were collected.All the data were analyzed with Excel software.Results:Among the 201 patients who were followed up,8.95%（1 8/201）presented with ADR,which included 10cases of defecate number increase,4 cases of constipation,and 4 cases of nausea.But the treatment continued because of the slight symptom.And the ADR rate of Coptis was closely connected with the dose,the medical compatibility,and the patients condition.Conclusion:This study explores the relationship between the ADR and the medical compatibility,as well as the heat-cold,deficiency-excess condition of patients.It points out a new way to study the rules of the occurrence,and the monitoring method of the ADR,which is in accordance with the characteristics of traditional Chinese medicine.