| 引用本文:牟稷征 刘 颖 仝小林 王丽霞.基于临床的含黄连中药汤剂安全性主动监测研究[J].世界中医药,2014,9(10):. |
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| 基于临床的含黄连中药汤剂安全性主动监测研究 |
| Active Safety Monitor on Traditional Chinese Medicine Decoction Containing Copits based on Clinical Study |
| 投稿时间：2014-06-18 |
| DOI：10.3969/j.issn.1673-7202.2014.10.036 |
| 中文关键词: 黄连 中药汤剂 不良发应 安全性 主动监测 |
| English Keywords:Coptis Chinese medicinal decoction Adverse drug reactions(ADR) Safety Active monitoring |
| 基金项目:国家重点基础研究发展计划（973计划）项目（编号:2010CB530601） |
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| 中文摘要: |
| 目的:探索中药汤剂安全性主动监测方法，并对含黄连的中药汤剂进行安全性主动监测，了解含中药黄连的汤剂不良反应发生情况和不良反应特征。方法:以访谈方式，对使用含黄连的中药汤剂的门诊患者进行用药调查，记录患者一般资料以及不良反应发生情况，计量资料用Excel表进行统计分析。结果:使用含黄连的中药汤剂的201例患者中，不良反应发生率为8.95%（18/201）。排便次数增多10例，便秘4例，恶心反胃4例，但症状较轻微，均未影响药物继续治疗。其不良反应发生与用药剂量、患者体质、药物配伍密切相关。结论:本项研究探讨了中药汤剂不良反应与患者体质寒热虚实、药物配伍的关系，为探讨中药不良反应发生规律、探讨符合中医药特点的不良反应监测方法提出了新思路。 |
| English Summary: |
| To explore the active monitoring method on the safety of traditional Chinese medicine decoction,and discuss the occurrence characters of the adverse drug reactions(ADR) of decoction containing Coptis.Methods:Patients who were prescribed the Traditional Chinese medicine decoction containing Coptis were interviewed,and the common data and the ADR characteristics were collected.All the data were analyzed with Excel software.Results:Among the 201 patients who were followed up,8.95%（1 8/201）presented with ADR,which included 10cases of defecate number increase,4 cases of constipation,and 4 cases of nausea.But the treatment continued because of the slight symptom.And the ADR rate of Coptis was closely connected with the dose,the medical compatibility,and the patients condition.Conclusion:This study explores the relationship between the ADR and the medical compatibility,as well as the heat-cold,deficiency-excess condition of patients.It points out a new way to study the rules of the occurrence,and the monitoring method of the ADR,which is in accordance with the characteristics of traditional Chinese medicine. |
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