To evaluate efficacy of Tongxinluo capsule in improving the nerve conduction velocity of patients with diabetic peripheral neuropathy.Methods:Randomized controlled trials were electronically retrieved from Cochrane Library,Pubmed Embase,CBM,CNKI,Wanfang Database,and so on.All articles were assessed according to the Cochrane Handbook for Systematic Reviews of interventions and then effective data were analyzed by RevMan 5.2 soft ware.Results:Fourteen randomized controlled trials involving 1078 patients were included.Results of Meta-analysis showed that there was statistical difference in the motor nerve conduction velocity of median nerve and common peroneal nerve［SMD=-1.10，95% CI(-1.54，-0.65)，P<0.01］and［SMD=-1.83，95% CI(-2.35，-1.30)，P<0.01.the sensory nerve conduction velocity of Median nerve and common peroneal nerve were improved［SMD=-1.27，95% CI(-1.80，-0.75)，P<0.01］and［SMD=-1.60，95% CI(-2.39，-0.81)，P<0.01］.Conclusion:The treatment plan of Tongxinluo capsule for Diabetic Peripheral Neuropathy is efficacy.