To investigate the effects and the influences of methods of inhibiting liver and strengthening spleen on psychological factors of patients with irritable bowel syndrome of diarrhea type(IBS-D). Methods: Forty nine patients with IBS-D were randomly divided into treatment group (n=30) and control group (n=19). Patients in the treatment group were given modified Tongxie Yaofang accompanied with Erzhu Jian. The control group gave patients Shenling Baizhu powder. The course of treatment was 1 month. Every patient filled the irritable bowel severity scoring system (IBS-SSS), self-rating anxiety scale (SAS) and self-rating depression scale (SDS). The curative effect of the two groups was compared. Results: No statistical significances were noted in the effective rate between two groups（P>0.05）. The scores of SAS and SDS were significantly decreased at the end of the treatment in both groups（P<0.05）, and no statistical significances were noted in the scores of SAS and SDS between two groups before and at the end of the treatment（P>0.05）. Conclusion: The two methods of inhibiting liver and strengthening spleen can alleviate the symptoms of IBS-D. The depressive and anxious emotions were improved at the end of the treatment in each group, but the therapeutic method of inhibiting liver doesnt show better effects on improving the psychological status.