To observe Wangshilianpu drink plus talcum,baical skullcap root and Yindari-4 decoction treating rat models with damp-heat syndrome,and its effect on inflammatory factors of Factors of IL-1β,IL-6 and TNF-α.Methods:Damp heat inflammation of rats model was set up,and there were four groups of rats including the blank group,model group,control group,the Chinese medicine group,and Mongolian medicine group.Different treatments were conducted and index,serum cytokines beta,IL- 6,IL- 1 TNF alpha test were observed by using enzyme-linked immunosorbent (ELISA).Results:The classic prescriptions of Chinese and Mongolian medicine treating warm diseases had reliable efficacy in the treatment of rats with damp-heat symptoms,especially in improving the reduced intake of water,runny stool and spat canthus secretion.ELISA detection showed that there was no significant improvement in the control group in terms of IL-1β,IL-6 and TNF-αbeta; Chinese traditional medicine group showed obvious difference in terms of TNF-α (P<0.01),and there was no significant improvement on IL- 1 beta and IL- 6 (P>0.05); the Mongolian group showed significant improvement on IL-6(P<0.05)and TNF-αv(P<0.01),and no significant difference on IL-1βv(P>0.05).Conclusion:Wanglianpu drink plus talcum,baical skullcap root and Yindari-4 decoction on relieving symptoms of damp-heat syndrome is practical and reliable.As for fever and inflammation caused by abdominal inflammation,although cytokines serum does not draw strong inspection data support,but the animal models have better physical signs in the late phase of treatment.ELISA detection shows that Chinese traditional medicine group has obvious difference in TNF alpha (P<0.01),and the Mongolian medicine group has obvious improvement in TNF alpha (P<0.01) and significant improvement in IL- 6 (P<0.05).