| 引用本文:黄倩兰1 阳仁达2 周 灿1 谢 力1.恒河猴感觉皮层手区切除后的脑功能重组[J].世界中医药,2014,9(12):. |
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| 恒河猴感觉皮层手区切除后的脑功能重组 |
| Rhesus sensory cortex hand area after resection of brain functional reorganization |
| 投稿时间：2014-12-08 |
| DOI：10.3969/j.issn.1673-7202.2014.12.004 |
| 中文关键词: 恒河猴 皮层切除 面口合谷收 脑功能重组 |
| English Keywords:Rhesus monkeys Sensory cortex resection Neurons discharge Brain function reorganization Diseases of the face and mouth apply Hegu |
| 基金项目:国家重点基础研究发展计划(“973”计划)项目：经脉体表特异性联系的生物学机制及针刺手法量效关系的研究(编号：2010CB530500) |
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| 中文摘要: |
| 目的：研究切除恒河猴感觉皮层手区对恒河猴感觉皮层脑功能重组的影响，探讨病理状况下大脑皮层对手区与面区感觉功能的调控作用是否发生代偿，揭示“面口合谷收”可能的生物学机制。方法：手术切除恒河猴感觉皮层手区，通过微电极细胞外记录寻找恒河猴感觉皮层SⅠ神经元的放电，观察其外周感受野的变化。结果：恒河猴感觉皮层手区切除后3个月、6个月、9个月，手区神经元的外周感受野消失，随着切除时间的延长，在已切除的手区可逐步记录到数量不等对面部和前臂刺激起反应的神经元，对面部刺激起反应的区域明显大于对前臂刺激起反应的区域。结论：1）感觉皮层手区功能的丧失导致与其毗邻的面区、前臂之间发生功能重组，面区和前臂区均逐步向手区扩展。2）功能重组似乎有一定的趋向性，即面区和手区之间的功能重组强于前臂区和手区。3）病理状况下大脑皮层手区和面区的功能重组可能是“面口合谷收”重要的生物学机制。 |
| English Summary: |
| To study the effect of removal of the hand area in rhesus monkeys sensory cortex on the reorganization of brain function，and explore in pathological situations whether the cerebral cortex would make a compensation for regulating the sensory function of face，mouth and the hand area，so as to reveal possible biological mechanisms of the “diseases of the face and mouth apply Hegu” theory.Methods:To obtain experimental models by Surgically removing the rhesus the hand area of sensory cortex，search for neuron discharge of rhesus monkeys sensory cortex through the extracellular recording by microelectrode，and observe changes in neurons periphery reception field within the area of the hand and face in sensory cortex.Results:Three months after resection of rhesus monkeys hand area in sensory cortex，those originally reacted to facial stimulation now react to both the stimulations from face and hands.Conclusion:1)The lose of the hand area in sensory cortex lead to functional reorganization both in the face and forearm area. At the same time， the face and forearm area are gradually expand to the hand area. 2)Functional reorganization seems to have a certain tendency， that is to say the functional reorganization between face area and hand area are stronger then the functional reorganization between forearm area and hand area. 3)Under pathological condition， the functional reorganization of hand area and face area in cerebral cortex maybe the biological mechanism of the “diseases of the face and mouth apply Hegu”. |
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