世界中医药

作者	单位
董佳容1 李艳芬2 陆金根3	1 上海交通大学医学院附属第九人民医院中医科，上海，200011； 2 上海闸北区市北医院肛肠科，上海 200435； 3 上海中医药大学附属龙华医院肛肠科，上海，200032

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中文摘要:

目的:观察益气开秘方治疗气阴亏损型慢性便秘的临床疗效。方法:将230例患者随机分为治疗组和对照组各115例。治疗组和对照组分别采用自拟益气开秘方及莫沙比利口服治疗。2组均治疗3个月后观察疗效。结果:治疗组105例总有效率为62.86%;对照组103例总有效率为40.78%。治疗组总有效率明显高于对照组(P<0.01);2组治疗前后症状和体征积分明显降低(P<0.05)，2组相比差异有统计学意义(P<0.05);2组治疗后中医症候、舌苔脉象及生活质量较治疗前明显好转(P<0.05)，2组相比差异有统计学意义(P<0.05);治疗后1个月随访，治疗组复发率和不良反应分别为20.63%、3.17%，对照组则为54.05%、32.43%，2组相比差异有统计学意义(P<0.01)。结论:“益气开秘方”治疗气阴亏损型慢性便秘在总体疗效和提高生活质量方面均比莫沙比利有优势，且复发率低，不良反应小。

English Summary:

To observe the clinical efficacy of “Yiqi Kaimi Recipe” in treating chronic constipation due to qi and yin deficiency.Methods:A total of 230 cases of chronic constipation patients were randomly divided into two groups，among whom 105 patients of the treatment group were treated with “Yiqi Kaimi Recipe”，and 103 patients of the control group were treated with mosapride; both groups received treatment for 90 days.Results: The total effective rate of the treatment group was remarkably better than that of the control group (P<0.01)，which were 62.86% and 46.67% respectively; the scores of symptoms and signs of both groups were significantly reduced after treatment (P<0.05)，and the difference between the two groups were significant (P<0.05); TCM syndrome classifications，tongue coating and pulse condition，and the quality of life score were significantly improved after treatment (P<0.05)，and there existed a significant difference between the groups (P<0.05).The recurrence rate and the incidence of adverse events of the treatment group and the control group were 20.63%，3.17%，and 54.05%，32.43% respectively，demonstrating significant difference between the two groups (P<0.01).Conclusion: Clinical observation showed that “Yiqi Kaimi Recipe” is superior to mosapride in terms of overall curative effect and improved life quality with a lower rate of recurrence and less adverse events.

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