| 引用本文:张 欣 吴 敏 阎秀菊 马 博.温敏型辛夷纳米凝胶的体内外释药规律研究[J].世界中医药,2014,9(12):. |
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| 温敏型辛夷纳米凝胶的体内外释药规律研究 |
| Study on the Drug Release of Temperature-sensitive Nanogels of Magnolia in Vitro and in Vivo |
| 投稿时间：2014-03-17 |
| DOI：10.3969/j.issn.1673-7202.2014.12.027 |
| 中文关键词: 辛夷挥发油 纳米 温敏凝胶 体外释药 体内释药 |
| English Keywords:Magnolia volatile oil, Nano Temperature-sensitive gel In vitro release In vivo release |
| 基金项目:上海交通大学医工结合专项基金（编号：YG2010MS14） |
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| 中文摘要: |
| 目的：研究温敏型辛夷纳米凝胶在体内和体外的释药规律。方法：体内释药规律研究采用在体大鼠鼻腔灌洗法，体外释药规律研究采用Franz扩散池法，利用HPLC法进行测定。结果：体外释药实验表明温敏型辛夷纳米凝胶12 h累积释放率为14％；采用动力学模型处理表明，温敏型辛夷纳米凝胶体内释药模式符合一级动力学过程，具有缓释效应。结论：温敏型辛夷纳米凝胶具备良好的缓释性能。 |
| English Summary: |
| To study the drug release of temperature-sensitive nanogels of Magnolia in vitro and in vivo. Methods: We investigated the process of in vitro drug release of temperature-sensitive nanogel of Magnolia with Franz diffusion cell. The regulation of nasal absorption of temperature-sensitive nanogel of Magnolia was investigated by the rat in situ nasal deposit method. The method of HPLC was conducted. Results: The study on drug release in vitro showed that the cumulative release rate in12 hours was 14%. The treatment of dynamic model showedthat the absorption process of this preparation fitted the first-order dynamics process， with slow-release effect. Conclusion: Temperature-sensitive nanogels of Magnolia has satisfactory slow-release effect. |
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