| 引用本文:王月茹1 谢 伟2 张 建2 席鹏洲2.星点设计-响应面分析法优选陕产铁筷子皂苷提取工艺[J].世界中医药,2014,9(12):. |
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| 星点设计-响应面分析法优选陕产铁筷子皂苷提取工艺 |
| Optimization of Extraction Technology for Helleborus Thibetanus Franch of Shaanxi by Central Composite Design-Response Surface Method |
| 投稿时间：2014-02-07 |
| DOI：10.3969/j.issn.1673-7202.2014.12.028 |
| 中文关键词: 铁筷子 星点设计 响应面 提取工艺 |
| English Keywords:Helleborus thibetanus Franch Central composite design Response surface methodology Extraction process |
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| 摘要点击次数: 1231 |
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| 中文摘要: |
| 目的：采用星点设计-响应面分析法优化陕产铁筷子皂苷的醇提取工艺。方法：选用乙醇为提取溶剂，以乙醇浓度、乙醇倍数、提取时间为自变量，铁筷子皂苷含量为因变量，采用响应面分析法优化该药材的提取工艺参数。结果：确定了提取工艺的最佳条件为：乙醇浓度70%，提取时间2 h，乙醇倍数6.5倍。在此条件下铁筷子提取物中皂苷的含量为0.065 8 g/g，二项式拟合复相关系数R2＝0.847 5。结论：该工艺方法能够用于陕产铁筷子皂苷的提取，并且具有简单、可行，预测性较好优势。 |
| English Summary: |
| To optimize the extraction technology of total dioscin from Helleborus thibetanus Franch of Shaanxi by central composite design response surface method.Methods:Ethanol was used as the extraction solvent，and the parameters of ex-traction technology of total dioscin from Helleborus thibetanus Franch were optimized by 3 factors and 5 levels.Independent variables were ethanol concentration，ethanol multiples and extraction time; dependent variable was the dioscin content.Results:The optimal extraction technology was realized by the following conditions：ethanol concentration was 70%，ethanol was multiplied with 6.5 times，and extraction time was 2 hours.The maximal yield of total dioscin reached to 0.065 8 g/g.Regression coefficient of the binomial fittingcomplex model was 0.8 475.Conclusion:The technology can be used as the extraction process of total dioscin from Helleborus thibetanus Franch of Shaanxi. |
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