The whole world is facing a big problem of the growing population aging，and how to postpone senescence is the hotspot in health study. Ancient and modern researches all confirmed that moxibustion was effective as an anti-aging therapy. This paper reviews the recent researches and reports on moxibustion as an anti-aging therapy， so as to summarize the different theories and regulation pathway. Moxibustion could eliminate the free radical， improve immune function， adjust the disorders of lipid metabolism， improve hemorrheology， adjust internal secretion， improve some trace elements and regulate neurotransmitters by regulatory pathways of apoptosis， cell cycle and the learning and memory to defer senescence. The study provides some reference to following researches in this field and clinical application.