To explore the biological foundation for the TCM theory of the interior-exterior relationship between the lung and the large intestine， we conducted an experiment to evaluate the content of eosinophils and neutrophils in bronchoalveolar lavage fluid (BALF) and IgE in blood serum after the asthma modeled mice were intervened with mirabilite at large intestines. Methods: Asthma model mice were established by OVA sensitization. Airway responsiveness， histopathology change， classification and counting of the cells of BALF and content of blood serum IgE were observed after large intestine was stimulated by mirabilite. Results: Compared with the normal rats， the asthma model rats airway resistance increased obviously， the number of eosinophils and neutrophils in BALF and IgE in blood serum significantly increased. After intervened with mirabilite， airway resistance decreased obviously， eosinophils and neutrophils in BALF and IgE in blood serum significantly lowered. Conclusion: Stimulating the large intestine by mirabilite showed beneficial effects in alleviating airway responsiveness and airway inflammation， and improving airway immune microenvironment in asthma mice model.