| 引用本文:钟相根，李宇航.宣白承气汤“承顺胃气”以“宣肺”的生物学机制[J].世界中医药,2015,10(01):. |
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| 宣白承气汤“承顺胃气”以“宣肺”的生物学机制 |
| Biological Mechanism of Xuanbai Chengqi Decoction which Smooth Stoma Qi to Disperse Lung Qi |
| 投稿时间：2014-12-05 |
| DOI：10.3969/j.issn.1673-7202.2015.01.008 |
| 中文关键词: 宣白承气汤 肺病治肠 肺与大肠相表里 |
| English Keywords:Xuanbai Chengqi Decoction Lung diseases treated intestine Lung and the large intestines being interior-exteriorly related |
| 基金项目:国家重点基础研究发展计划（973计划）项目（编号：2009CB522704）；北京中医药大学“经方现代应用关键科学问题的基础研究”创新团队（编号：2011-CXTD-04） |
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| 中文摘要: |
| 承气汤出自仲景《伤寒论》，是治疗阳明腑实证的主方。吴鞠通化裁承气汤，创制了“肺肠同治”的代表方剂宣白承气汤，被广泛用于治疗痰热壅肺、腑气不通等肺系疾病。作者的研究团队开展了多中心随机对照的临床研究，为宣白承气汤治疗慢性阻塞性肺疾病痰热壅肺证提供循证医学证据。在此基础上，系统探讨了宣白承气汤“承顺胃气”以“宣肺”的生物学机制。历经多年的RCT研究证实了宣白承气汤可有效治疗慢性阻塞性肺疾病急性加重痰热壅肺证，创新了COPD中医新治法，提高了临床疗效。宣白承气汤“承顺胃气”以“宣肺”的生物学机制与调节肺组织氧化/抗氧化失衡、黏液高分泌、黏膜免疫、气道重构、炎症反应、神经肽分泌等密切相关。尤其是对神经肽通路的研究，为揭示宣白承气汤“承顺胃气”以“宣肺”的机制及本方临床应用治疗肺系疾病提供了实验依据。 |
| English Summary: |
| Chengqi Decoction from Treatise on Febrile Diseases by Zhang Zhongjing， is the representative formular of yang brightness fu-organ syndrome. Wu Jutong developed Chengqi Decoction by creating Xuanbai Chengqi Decoction， which embodied the idea of “simultaneous treatment of lung and intestine”， and widely used to treat phlegm heat obstructing lung， fu qi being obstructed， etc. We had carried out multi-centered randomized controlled study， in order to provide laboratory proof of Xuanbai Chengqi Decoction curing chronic obstructive pulmonary disease of phlegm heat obstructing， and brought to light biological mechanism of Xuanbai Chengqi Decoction which smooth stoma qi to disperse lung qi. RCT research had confirmed that Xuanbai Chengqi Decoction is effective for acute exacerbation of chronic obstructive pulmonary disease with phlegm heat syndrome; supplement novel TCM treatment for COPD. The mechanism of dispersing lung qi is associated with regaining oxidant / antioxidant balance， improve mucus hypersecretion， airway remodeling， mucosal immune， inflammatory reaction， neuropeptides etc. The finding of neuropeptide pathways in particular has provided laboratory proof of the Chinese formula. |
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