To investigate the clinical efficacy of Shaoyao Gancao decoction combined with flunarizine in treating nerve headache.Methods:Eighty three patients with nerve headache were randomly divided into a control group (n=40) and a treatment group (n=43).Patients in the control group were treated with oral administration of flunarizine before the bed-time，5 mg / day，1 times / day; while patients in the treatment group were treated with self-made decoction-the Shaoyao Gancao decoction combined with flunarizine.We observed the number of headache onsets，the duration of headache and the degree of headache.Results:Compared with those in the control group，the clinical symptoms in the treatment group were significantly improved.The efficiency rate of the control group was 75%，while that of the treatment group was 90.6%.After treatment，the headache frequency，duration and severity of headache were all significantly decreased than before treatment in both groups，and the differences were statistically significant (P<0.05); and the indicators in treatment group were significantly lower than those of the control group，and the difference was of statistically significance (P<0.05).Conclusion:Treating nerve headache with Shaoyao Gancao decoction combined with flunarizine has significant treatment effect，which can improve the life quality of the patients，relieve the headache of the patients，and improve the number of headache onsets，the duration of headache and the degree of headache.It is worthy of further research and development.