| 引用本文:韩俊阁，刘晓燕，张刘扛，郭霞珍.“肺与大肠相表里”机理的研究——高氧刺激对肺肠黏膜免疫因子含量表达的影响[J].世界中医药,2015,10(01):. |
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| “肺与大肠相表里”机理的研究——高氧刺激对肺肠黏膜免疫因子含量表达的影响 |
| Mechanism Research on ‘Lung and Large Intestine being interior-exteriorly Related’——Effect of Hyperoxia on the Expression of CK of Lung and Intestinal Mucosa |
| 投稿时间：2014-06-20 |
| DOI：10.3969/j.issn.1673-7202.2015.01.021 |
| 中文关键词: 肺与大肠相表里 高氧 细胞因子 |
| English Keywords:Lung and Large Intestine being interior-exteriorly related Hyperoxia Cytokines |
| 基金项目:国家重点基础研究发展计划（973计划）资助项目（编号：2009CB522706） |
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| 中文摘要: |
| 目的：通过观察高氧下大鼠肺、肠黏膜细胞因子IL-1β，IL-2、IL-6、TNF-α含量的变化，探讨“肺与大肠相表里”的生物学机制。方法：实验设立正常空气组、高氧组（吸入40%浓度氧），比较2组肺泡灌洗液、肠黏膜灌洗液中IL-1β，IL-2、IL-6、TNF-α的含量。结果：造模5 d后，大鼠肺泡灌洗液和肠黏膜灌洗液中的IL-1β、IL-2、IL-6含量均较正常空气组呈现明显下降（P<0.05）；大鼠肺泡灌洗液及肠黏膜灌洗液的TNF-α也表现为较正常空气组下降的趋势（P>0.05）。结论：肺肠之间在黏膜免疫方面具有同步性，这可能是肺与大肠表里关系的重要的生物学基础。 |
| English Summary: |
| To observe the hyperoxia stimulus to lung and intestinal mucosa of rats and the changes of the content of cytokines IL-1beta，IL-2，IL-6，TNF alpha，so as to explore the biological mechanisms of ‘Lung and Large Intestine being interior-exteriorly related’.Methods:The experiment set up two groups-normal group and the hyperoxia one-which the oxygen concentration was 40%.The content of IL-1beta，IL-2，IL-6，the TNF alpha of Bronchoalveolar lavage fluid and intestinal mucosa lavage fluid was compared.Results:After 5 days，compared with normal group，IL-1beta，IL-2 and IL-6 levels of both the Bronchoalveolar lavage fluid and intestinal mucosa lavage fluid dropped significantly (P<0.05)，and TNF alpha of both the Bronchoalveolar lavage fluid and Intestinal mucosa lavage fluid showed a trend of decline.Conclusion:Lung and Large Intestine have the synchronicity from the perspective of mucosal immunity，and it may be the important biological basis for lung and large intestine exterior-interior relationship. |
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