The incidence of depression after myocardial infarction brings people to realize that there is a cardio-cerebral pathological connection.Patients experiencing an acute myocardial infarction (AMI) have a three times higher chance to develop depression.Vice versa，depressive symptoms increase the risk of cardiovascular incidents.The co-existence of both conditions is associated with substantially worse prognosis.Although the underlying mechanism of the interaction is largely unknown，inflammation is thought to be of pivotal importance.AMI-induced peripheral cytokines release may cause cerebral endothelial leakage and the integrity of the blood-brain barrier damage and hence induces a neuroinflammatory reaction.The neuroinflammation may persist even longer after the initial peripheral inflammation has been subsided.This paper attempts to reveal the relationship between the heart and brain from the mechanism of depression after myocardial infarction and provide a biological basis for the treatment of depression after myocardial infarction for clinical application.