| 引用本文:管咏梅，刘红宁，杨明，陈振华，陈丽华，张妮.白头翁总皂苷-羟丙基-β-环糊精包合物微丸生物利用度研究[J].世界中医药,2015,10(03):. |
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| 白头翁总皂苷-羟丙基-β-环糊精包合物微丸生物利用度研究 |
| Study on the Bioavailability of Pulsatilla Total Saponins-hydroxypropyl-β-cyclodextrin inclusion Clathrate Pellets |
| 投稿时间：2015-02-02 |
| DOI：10.3969/j.issn.1673-7202.2015.03.008 |
| 中文关键词: 白头翁总皂苷 包合物 微丸 生物利用度 |
| English Keywords:Pulsatilla total saponins Inclusion Pellet Bioavailability |
| 基金项目:科技部十二五国家重大新药创制科技重大专项（编号：013ZX09103-002-001）；江西省自然科学基金项目（编号：20122BAB215041）；江西省教育厅科技落地计划项目（编号：赣财教［2011］243号） |
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| 中文摘要: |
| 目的：研究白头翁总皂苷-羟丙基-β-环糊精包合物微丸的生物利用度。方法：分别单剂量口服给药白头翁总皂苷和白头翁总皂苷-羟丙基-β-环糊精包合物微丸（200 mg/kg），采用LC-MS法测定大鼠血药浓度，根据大鼠体内血药浓度经时过程,计算相应的药代动力学参数。结果：白头翁总皂苷和白头翁总皂苷-羟丙基-β-环糊精包合物微丸AUC分别为574.82和1776.32 μg/(L·h)。结论：白头翁总皂苷制成羟丙基-β-环糊精包合物微丸后生物利用度显著提高。 |
| English Summary: |
| To explore the bioavailability of Pulsatilla total saponins- hydroxypropyl -β- cyclodextrin clathrate pellets. Methods: The total Saponin of Pulsatilla Chinensis Regel and its OH-β-CD clathrate Pellets (200 mg/kg) were administered in rats respectively, the plasma levels were determined by LC-MS. Then the corresponding pharmacokinetic parameters based on the time process of blood drug concentration were calculated. Results: AUC of the Total Saponin of Pulsatilla Chinensis Regel and its OH-β-CD inclusion complex were 574.82 and 1776.32μg/L·h. Conclusion: The bioavailability of pulsatilla total saponins can be improved significantly by the technology of hydroxypropyl-β-cyclodextrin inclusion. |
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