To discuss the clinical efficacy of the Wenzhong Jianpi (middle-warming, spleen-tonifying) method in chronic peptic ulcers and chronic non-specific ulcerative cases belonging to the pattern of Xuhan (deficiency- cold). Methods: We randomized 120 cases of Xuhan featured chronic peptic ulcers and chronic non-specific ulcerative colitis patients into a 1∶1 treatment group (60 cases) and a control group (60 cases). The treatment group used self-designed prescription Wenzhong Jianpi Yin, the control group adopted ranitidine or sulfasalazine (enteric coated tablets) respectively for a treatment course of two months. Results: For alleviating of TCM syndrome symptoms, the treatment group had a total significant effective rate of 75.00%, and total effective rate of 83.33%; which were 56.67% and 75.00% of the control group. For treating chronic non-specific ulcerative colitis, the treatment group had a total significant effective rate of 40.00% and total effective rate of 73.33%; Control group was at 44.44% and 80.95% respectively. For treating Chronic Peptic Ulcers, the treatment group had a total significant effective rate of 42.22% and total effective rate of 73.33%; Control group was at 52.38% and 80.95% respectively. Group comparison had no statistical significance (P>0.05). Conclusion: Wenzhong Jianpi method has satisfactory efficacy in treating chronic peptic ulcers and chronic non-specific ulcerative colitis.