世界中医药

目的：评价三黄清胃丸治疗寒热错杂型消化性溃疡的临床疗效。方法：选取2013年1月至2013年12月我院门诊和住院收治的寒热错杂型消化性溃疡患者94例，随机分为对照组和治疗组各47例，对照组给予化药治疗，治疗组在化药治疗的基础上加三黄清胃丸内服。评价胃镜疗效、Hp疗效、中医症候疗效以及不良反应发生情况和远期复发情况。结果：经过4周治疗后，治疗组痊愈率为65.96%，总有效率为93.62%，显著高于对照组的51.06%和82.98%（P<0.05）；治疗组治疗后14C-DPM值均显著低于治疗前和对照组，且Hp转阴率显著高于对照组（P<0.05）；治疗组痊愈率和总有效率明显高于对照组（P<0.05），但不良反应发生率和远期复发率均显著低于对照组（P<0.05）。结论：与单纯的化药治疗相比，加服三黄清胃丸治疗寒热错杂型消化性溃疡能显著提高近远期临床疗效，且不良反应较少。

English Summary:

To study the safety and efficacy of Sanhuang Qingwei pill in the treatment of peptic ulcer (PU) with cold-heat-intertwisting syndrome. Methods: Ninety four patients with PU with cold-heat-intertwisting syndrome from June 2013 to December 2013 were selected and randomly divided into control group (47 cases) and observation group (47 cases). Patients in the control group received standard triple therapy while patients in the observation group received Sanhuang Qingwei pill combined with standard triple therapy. Before and after treatment of 4 weeks, the short-time and long-time effect and adverse reaction were compared between two groups. Results: After treatment of 4 weeks, the cure rate was 65.96% and the total effective rate was 93.62% in the observation group, which was significantly higher than those 51.06% and 82.98% of the control group (P<0.05); the eradication rate of Hp of observation group by 14C-DPM were significantly higher than that of the control group (P<0.05); the cure rate and total effective rate were significantly higher than those in the control group (P<0.05); the rate of adverse reactions and recurrence of the observation group were significantly lower than those of the control group (P< 0.05). Conclusion: Compared with the triple therapy, treatment of PU with cold-heat-intertwisting syndrome by Sanhuang Qingwei pill can improve clinical effect and reduce incidence of adverse reactions. This method is worth promoting in clinical practices.

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