To investigate the impact of warming and activating meridian prescription combined with meridian activating massage on cervical mechanical properties of patients with cervical spondylosis. Methods: Two hundred and twenty cases with cervical spondylosis were selected from massage outpatient in our hospital during the period from July 2013 to July 2014, and were divided into observation group and control group according to a random number table, 110 cases in each group. Control group were given warming and activating meridian prescription combined with conventional massage, the observation group were given warming and activating meridian prescription combined with meridian activating massage, the median frequency (MF) and maximum value of active contraction force (MVC) with neck flexion and extension 50% of the of cervical paraspinal muscles, trapezius and sternocleidomastoid were measured in isokinetic speedometer and surface electromyography. Results: MVC value with flexion and extension movement exercise 50% after treatment of the observation group significantly increased, the difference was statistically significant compared with before treatment (P<0.05), and the difference was statistically significant compared with the control group (P<0.05); MF values of cervical paraspinal muscles, trapezius and sternocleidomastoid of the observation group after the treatment significantly increased, the difference was statistically significant compared with before treatment (P<0.05), and the difference was statistically significant compared with the control group (P<0.05). Conclusion: Warming and activating meridian prescription combined with meridian activating massage in treatment of cervical spondylosis has better clinical efficacy, can significantly improve the mechanical properties of cervical patients.