| 引用本文:齐月1,2，于世家2.木丹颗粒联合甲钴胺治疗痛性糖尿病周围神经病变的临床观察[J].世界中医药,2015,10(03):. |
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| 木丹颗粒联合甲钴胺治疗痛性糖尿病周围神经病变的临床观察 |
| The Clinical Effect of Mudan Particles Combined with Mecobalamine in the Treatment of Painful Diabetic Peripheral Neuropathy |
| 投稿时间：2014-10-12 |
| DOI：10.3969/j.issn.1673-7202.2015.03.013 |
| 中文关键词: 痛性糖尿病周围神经病变 木丹颗粒 甲钴胺 |
| English Keywords:Painful diabetic peripheral neuropathy Mudan Particles Mecobalamine |
| 基金项目:国家自然科学基金面上项目(编号：81072912) |
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| 中文摘要: |
| 目的:观察木丹颗粒联合甲钴胺片治疗痛性糖尿病周围神经病变(Painful Diabetic Peripheral Neuropathy,PDPN)患者的临床疗效。方法:将100例PDPN患者随机分为治疗组50例和对照组50例。在控制血糖基础上,对照组给予甲钴胺治疗4周;治疗组在对照组治疗基础上加服木丹颗粒治疗4周,疗程结束后,观察2组临床疗效及治疗前后腓总神经传导速度(NCV)变化。结果:2组治疗后TCSS均有改善(P<0.05),但以治疗组改善明显;2组对疼痛均有缓解,但治疗组总有效率为86%,高于对照组;治疗组治疗后,腓总神经运动传导速度及感觉传导速度疗效均优于对照组(P<0.05)。结论:木丹颗粒联合甲钴胺辅助治疗PDPN,对神经传导速度及疼痛的改善有良好作用,且无明显不良反应。 |
| English Summary: |
| To investigate the efficacy of Mudan Particles combined with mecobalamine in the treatment of painful diabetic peripheral neuropathy (PDPN). Methods: One hundred patients with PDPN were randomly divided into treatment group (n=50) and the control group (n=50).Based on the basic control of blood glucose, the control group were treated with mecobalamine; the treatment group were treated with Mudan Particles in addition to the control group.Observe the treatment effect and the peroneal nerve conduction velocity of two groups before and after treatment.Results: TCSS of the two groups improved after treatment (P<0.05, but the treatment group improved rather significantly. For pain, the total effective rate of the treatment group (86％) was higher than that of the control group.After treatment, MCV and SCV of common personal nerve of the treatment group were faster than those of the control group(P<0.05).Conclusion: Mudan Particles combined with mecobalamine have a good effect on nerve conduction velocity improvement and pain relief in the treatment of PDPN, and have no significant adverse reaction. |
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