| 引用本文:肖小惠，李惠林，刘德亮，刘雪梅，张志玲，赵恒侠，翁妍珊.益气养阴活血法治疗2型糖尿病的临床疗效观察[J].世界中医药,2015,10(03):. |
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| 益气养阴活血法治疗2型糖尿病的临床疗效观察 |
| The Clinical Effect Observation of Yiqi Yangyin Huoxue Method in Treating Type 2 Diabetes |
| 投稿时间：2014-12-16 |
| DOI：10.3969/j.issn.1673-7202.2015.03.015 |
| 中文关键词: 益气养阴活血法 2型糖尿病 胰岛素抵抗 血脂紊乱 高凝状态 |
| English Keywords:Yiqi Yangyin Huoxue Method Type 2 diabetes Insulin resistance Dyslipidemia High coagulation state |
| 基金项目:国家自然科学基金项目(编号:81173253) |
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| 中文摘要: |
| 目的:为观察益气养阴活血法对2型糖尿病的临床疗效。方法:将入选的70例患者随机分为治疗组37例和对照组33例,对照组予糖尿病教育、饮食控制、运动治疗及二甲双胍,治疗组加用以益气养阴活血为主的中药治疗。观察治疗前后所有患者的空腹血糖(FBG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、血脂、凝血功能、胰岛素敏感指数(ISI)、体重指数(BMI)及中医症候积分的变化情况。结果:治疗16周后,2组均能较好地降低空腹血糖(FBG)、餐后2 h血糖(2 hPG)及糖化血红蛋白(HbA1c)。治疗组还能提高空腹胰岛素(FINS)、胰岛素敏感指数(ISI)、凝血酶原时间（PT）、活化部分凝血激酶时间(APTT）、胆固醇(TC)、三酰甘油(TG)、纤维蛋白原(FIB)、中医症候疗效,其差异具有显著性意义(P<0.05或P<0.001),疗效明显优于对照组(P<0.05或P<0.001);对照组空腹胰岛素(FINS)、胰岛素敏感指数(ISI)的改善不明显。结论:益气养阴活血法不仅能显著降低患者的血糖、血脂及糖化血红蛋白,改善血液高凝状态,且还可减轻胰岛素抵抗及降低中医症候积分。 |
| English Summary: |
| To observe the clinical effect of Yiqi Yangyin Huoxue Method on type 2 diabetes. Methods: Seventy patients with type 2 diabetes were randomly divided into treatment group (37 cases) and control group (33 cases). Control group received diabetes education, diet control, exercise and metformin treatment. Except the same therapy as control group, treatment group was treated with herbs in Yiqi Yangyin Huoxue Method, which has the function of reinforcing qi, nourishing yin and promoting circulation. The following items were compared before and after the therapy: blood glucose (FBG), 2 h postprandial blood glucose (2 hPG), glycosylated hemoglobin (HbA1c), fasting insulin (FINS), blood lipid, blood coagulation function and insulin sensitivity index (ISI), body mass index (BMI) and TCM syndrome integral. Results: After 16-weeks treatment, the fasting blood glucose (FBG), 2 h postprandial blood glucose (2 hPG) and glycosylated hemoglobin (HbA1c) decreased in both two groups effectively. Moreover, it worked better in improving fasting insulin (FINS), insulin sensitivity index (ISI), prothrombin time (PT), activated partial thromboplastin time (APTT), cholesterol (TC), triglyceride (TG), fibrinogen (FIB) and TCM syndrome integral in treatment group. The difference between the two groups was significant (P<0.05 or P<0.001). Curative effect of the treatment group was significantly higher than that of the control group (P<0.05 or P<0.001). On the other hand, fasting insulin (FINS) and insulin sensitivity index (ISI) in control group did not show obvious changes. Conclusion: Herbs in Yiqi Yangyin Huoxue method can significantly reduce blood lipid, blood glucose and glycosylated hemoglobin (HbA1c), improve blood hypercoagulable state, and reduce insulin resistance and TCM syndrome integral. |
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